Scopolamine-Morphine Anaesthesia by Van Hoosen

Prior to administration, wipe area behind the ear with a clean, dry tissue to ensure it is dry. Transdermal system should not be cut only one transdermal system should be worn at any time. To prevent postoperative nausea and vomiting, apply the evening before scheduled surgery.įor use in cesarean section, apply 1 hour prior to surgery to minimize exposure of the fetus to the drug. To prevent motion sickness, apply at least 4 hours (e.g., 4–24 hours) before anticipated exposure to motion. (See CNS Effects under Cautions.) Transdermal Administration When used preoperatively, administer 30–60 minutes prior to the anticipated time of induction of anesthesia or at the same time other preanesthetic medications (e.g., opiates, sedatives) are administered, since scopolamine may cause behavioral changes in patients with pain or anxiety. When administered orally or IM for the prevention of motion sickness, generally administer 1 hour (range: 0.5–1.5 hours) before anticipated exposure to motion. Scopolamine Dosage and Administration AdministrationĪdminister orally or by IM, direct IV, or sub-Q injection also may administer percutaneously by topical application of a transdermal system (Transderm Scop ).

Has been used for symptomatic treatment of parkinsonian syndrome however, antimuscarinincs generally have been replaced with dopaminergic drugs. Has greater sedative, antisecretory (e.g., on respiratory secretions), and antiemetic effects than atropine however, less effective than atropine in preventing intraoperative cholinergic effects (e.g., cardiac arrhythmias, hypotension, bradycardia). Used preoperatively and in obstetrics in conjunction with analgesics or sedatives to produce tranquilization and amnesia however, benzodiazepines may be preferred. Has been used preoperatively to inhibit salivation and excessive respiratory tract secretions, but use of general anesthetics (e.g., thiopental, halothane) that do not stimulate secretions has reduced the need for this use. Used transdermally for prevention of nausea and vomiting associated with recovery from anesthesia and surgery, but efficacy is equivocal. Transdermal administration is effective and has fewer adverse effects and increased duration compared with oral administration.

Oral or IM administration usually reserved for patients exposed to short periods of intense motion or those highly susceptible to motion because these routes have short duration of effect and high incidence of adverse effects. Prevention of motion-induced nausea and vomiting considered most effective drug for this use.

Written by ASHP.Īntimuscarinic naturally occurring tertiary amine. Drug class: Antimuscarinics/Antispasmodics

Scopolamine-Morphine Anaesthesia by Van Hoosen